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A highly sensitive LC-MS/MS method for the simultaneous quantification of Nitroglycerin and its two major metabolites in human plasma

  Structure: Nitroglycerin 1,2 Dintroglycerin 1,3 Dintroglycerin   Introduction: Nitroglycerin is a colorless, oily, explosive liquid produced by nitrating glycerol. Nitroglycerin forms free radical nitric oxide, which activates guanylate cyclase resulting in increased guanosine 3’5’monophosphate in smooth muscles and other tissues. These events lead to dephosphorylation of myosin light chain, which...

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01 May
5
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A Highly Sensitive LC-MS/MS Method for the Quantification of Formoterol in Human plasma.

Background: Formoterol is a long-acting β2 agonist (LABA) used as a Bronchodilator in the management of asthma and chronic obstructive pulmonary disease. Recommended low doses are to be used as over dosing may lead to nausea, vomiting, headache, tremor, somnolence, palpitations, tachycardia, ventricular arrhythmias, metabolic acidosis,...

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01 February
3
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A Highly Sensitive LC-MS/MS Method for the Simultaneous Quantification of Bupropion, Hydroxy Bupropion, Erythro Hydro Bupropion and Threo Hydro Bupropion in Human plasma

Structure: Method: Bupropion is a relatively weak inhibitor of the neuronal uptake of norepinephrine and dopamine, and does not inhibit monoamine oxidase or the re-uptake of serotonin. It is indicated for the treatment of major depressive disorder and prevention of seasonal major depressive episodes in patients with...

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01 September
14
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A Highly Sensitive LC-MS/MS Method for the Quantification of Tetrabenazine and DihydroTetrabenazine in Human plasma

Structure: Method: Tetrabenazine is a drug for the symptomatic treatment of hyperkinetic movement disorders. Tetrabenazine metabolises rapidly and extensively by carbonyl reductase to the active metabolites α-hydroxy tetrabenazine and β-hydroxy tetrabenazine (Dihydrotetrabenazine as racemic mixture), hence a selective and sensitive method at an LLOQ of about 5 pg/mL for...

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09 July
8