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A Highly Sensitive LC-MS/MS Method for the Simultaneous Quantification of Bupropion, Hydroxy Bupropion, Erythro Hydro Bupropion and Threo Hydro Bupropion in Human plasma

Structure: Method: Bupropion is a relatively weak inhibitor of the neuronal uptake of norepinephrine and dopamine, and does not inhibit monoamine oxidase or the re-uptake of serotonin. It is indicated for the treatment of major depressive disorder and prevention of seasonal major depressive episodes in patients with...

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01 September
10
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A Highly Sensitive LC-MS/MS Method for the Quantification of Tetrabenazine and DihydroTetrabenazine in Human plasma

Structure: Method: Tetrabenazine is a drug for the symptomatic treatment of hyperkinetic movement disorders. Tetrabenazine metabolises rapidly and extensively by carbonyl reductase to the active metabolites α-hydroxy tetrabenazine and β-hydroxy tetrabenazine (Dihydrotetrabenazine as racemic mixture), hence a selective and sensitive method at an LLOQ of about 5 pg/mL for...

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09 July
6
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A Highly Sensitive LC-MS/MS Method for the Quantification of Cabergoline in Human Plasma

Cabergoline: Chemical Structure Introduction Cabergoline (brand names: Caberlin, Dostinex and Cabaser), an ergot derivative, is a potent dopamine 2 receptor agonist. Rat studies have shown that Cabergoline has a direct inhibitory effect on pituitary lactotroph (prolactin) cells. It is frequently used as a first-line agent in the management of prolactinomas due to its higher affinity for D2 receptors, less severe side...

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05 April
41
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A Novel LC-MS/MS Method for the Quantification of Levothyroxine (T4) in Human Serum

Structure: Method: Levothyroxine or L-thyroxine is a synthetic thyroid hormone that is chemically identical to thyroxine (T4), which is naturally secreted by the follicular cells of the thyroid gland. It is used to treat thyroid hormone deficiency, and occasionally to prevent the recurrence of thyroid cancer.   Levothyroxine is an endogenous molecule, hence requires specially treated matrix for...

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03 February
168