Introduction: Nitroglycerin is a colorless, oily, explosive liquid produced by nitrating glycerol. Nitroglycerin forms free radical nitric oxide, which activates guanylate cyclase resulting in increased guanosine 3’5’monophosphate in smooth muscles and other tissues. These events lead to dephosphorylation of myosin light chain, which... Read More
Formoterol is a long-acting β2 agonist (LABA) used as a Bronchodilator in the management of asthma and chronic obstructive pulmonary disease. Recommended low doses are to be used as over dosing may lead to nausea, vomiting, headache, tremor, somnolence, palpitations, tachycardia, ventricular arrhythmias, metabolic acidosis,... Read More
Betahistine, a vasodilator, is most commonly used to treat the symptoms of Meniere’s disease, vertigo and tinnitus.
Betahistine chemically is 2-[2-(methylamino) ethyl] pyridine and is formulated as the dihydrochloride salt. Betahistine is rapidly converted to its major metabolite 2 pyridyl acetic acid (2-PAA) by monoamino oxidase... Read More
Bupropion is a relatively weak inhibitor of the neuronal uptake of norepinephrine and dopamine, and does not inhibit monoamine oxidase or the re-uptake of serotonin. It is indicated for the treatment of major depressive disorder and prevention of seasonal major depressive episodes in patients with... Read More
Tetrabenazine is a drug for the symptomatic treatment of hyperkinetic movement disorders. Tetrabenazine metabolises rapidly and extensively by carbonyl reductase to the active metabolites α-hydroxy tetrabenazine and β-hydroxy tetrabenazine (Dihydrotetrabenazine as racemic mixture), hence a selective and sensitive method at an LLOQ of about 5 pg/mL for... Read More